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N106
CAS No. 862974-25-2
N106( N-106 | N 106 )
Catalog No. M27902 CAS No. 862974-25-2
N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 110 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 169 | In Stock |
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| 25MG | 377 | In Stock |
|
| 50MG | 548 | In Stock |
|
| 100MG | 784 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameN106
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NoteResearch use only, not for human use.
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Brief DescriptionN106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.
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DescriptionN106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.(In Vitro):N106 (10 min) increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation. These effects are sustained at 24 h in cardiomyocytes.(In Vivo):N106 (10 mg/kg) significantly improves ventricular function in mice with heart failure. N106(10 mg/kg; i.v.) exhibits a half-life of 65.4 min and a Cmax of ～2.24 μM.
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In Vitro——
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In Vivo——
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SynonymsN-106 | N 106
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PathwayOthers
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TargetOther Targets
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RecptorHD1-A|HD1-B|HD2|HDAC1|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9|HDAC10|HDAC11
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Research Area——
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Indication——
Chemical Information
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CAS Number862974-25-2
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Formula Weight354.38
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Molecular FormulaC17H14N4O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (176.36 mM)
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SMILESCOc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zappasodi R, et al. Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas. Int J Cancer. 2014 Nov 1;135(9):2034-45.
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