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N106

CAS No. 862974-25-2

N106( N-106 | N 106 )

Catalog No. M27902 CAS No. 862974-25-2

N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 110 In Stock
5MG 92 In Stock
10MG 169 In Stock
25MG 377 In Stock
50MG 548 In Stock
100MG 784 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    N106
  • Note
    Research use only, not for human use.
  • Brief Description
    N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.
  • Description
    N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.(In Vitro):N106 (10 min) increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation. These effects are sustained at 24 h in cardiomyocytes.(In Vivo):N106 (10 mg/kg) significantly improves ventricular function in mice with heart failure. N106(10 mg/kg; i.v.) exhibits a half-life of 65.4 min and a Cmax of ～2.24 μM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    N-106 | N 106
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HD1-A|HD1-B|HD2|HDAC1|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9|HDAC10|HDAC11
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    862974-25-2
  • Formula Weight
    354.38
  • Molecular Formula
    C17H14N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (176.36 mM)
  • SMILES
    COc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zappasodi R, et al. Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas. Int J Cancer. 2014 Nov 1;135(9):2034-45.
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