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BMS-8
CAS No. 1675201-90-7
BMS-8( BMS8 | BMS 8 | BMS-8 )
Catalog No. M27858 CAS No. 1675201-90-7
BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 126 | In Stock |
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| 25MG | 235 | In Stock |
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| 50MG | 352 | In Stock |
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| 100MG | 523 | In Stock |
|
| 200MG | 728 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBMS-8
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.
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DescriptionBMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.(In Vitro):BMS-8 has a more stable binding mode with one PD-L1 monomer than the other and the small-molecule inducing PD-L1 dimerization was further stabilized by the non-polar interaction of Ile54, Tyr56, Met115, Ala121, and Tyr123 on both monomers and the water bridges involved in ALys124.
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In VitroBMS-8 tends to have a more stable binding mode with one PD-L1 monomer than the other and the small-molecule inducing PD-L1 dimerization was further stabilized by the non-polar interaction of Ile54, Tyr56, Met115, Ala121, and Tyr123 on both monomers and the water bridges involved in ALys124.
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In Vivo——
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SynonymsBMS8 | BMS 8 | BMS-8
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PathwayImmunology/Inflammation
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TargetPD-1/PD-L1
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RecptorWnt/beta-catenin
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Research Area——
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Indication——
Chemical Information
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CAS Number1675201-90-7
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Formula Weight494.429
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Molecular FormulaC27H28BrNO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (168.54 mM)
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SMILESCc1c(COc2ccc(CN3CCCCC3C(O)=O)cc2Br)cccc1-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Stoops SL, Pearson AS, Weaver C, Waterson AG, Days E, Farmer C, Brady S, Weaver CD, Beauchamp RD, Lindsley CW. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem Biol. 2011 May 20;6(5):452-65.
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