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BAY 73-1449

CAS No. 693790-96-4

BAY 73-1449( BAY73-1449 | BAY 73-1449 )

Catalog No. M27855 CAS No. 693790-96-4

BAY 73-1449 is a selective and potent antagonist of the prostacyclin receptor(IC50<0.1 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 90 In Stock
5MG 79 In Stock
10MG 131 In Stock
25MG 227 In Stock
50MG 319 In Stock
100MG 425 In Stock
200MG 572 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    BAY 73-1449
  • Note
    Research use only, not for human use.
  • Brief Description
    BAY 73-1449 is a selective and potent antagonist of the prostacyclin receptor(IC50<0.1 nM).
  • Description
    BAY 73-1449 is a selective and potent antagonist of the prostacyclin receptor(IC50<0.1 nM).(In Vivo):In male Wistar rats, BAY 73-1449 (0.1-1 mg/kg; i.v.) significantly reduced splenic shunt vessel outflow without affecting mesenteric inflow. BAY 73-1449 (1-5 mg/kg; s.c.) has no effects on portal pressures and the degree of porto-systemic shunting in rats.
  • In Vitro
    ——
  • In Vivo
    BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats.BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats.BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats. Animal Model:Male Wistar rats (250-350 g) are ligated portal veinDosage:0.1, 1 mg/kg.Administration:A single i.v.Result:Significantly reduced shunt flow without affecting mesenteric flow.
  • Synonyms
    BAY73-1449 | BAY 73-1449
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    RhoA| Lbc
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    693790-96-4
  • Formula Weight
    425.488
  • Molecular Formula
    C26H23N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (587.57 mM)
  • SMILES
    OC(=O)[C@H](Cc1ccccc1)Nc1cc(ncn1)-c1ccc(OCc2ccccc2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Francesca FANELLI, et al. Compounds and composition for use in the inhibition of the lbc-rhoa interaction, in particular for the treatment of cancer. WO2015028929A1.
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