Cart
sales@molnova.com
Apomine
CAS No. 126411-13-0
Apomine( APB-231-A-2 | SK&F-99085 | SR-45023A | SR-9223i | APB-231-A2 )
Catalog No. M27850 CAS No. 126411-13-0
Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase and stimulates low-density lipoprotein receptor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 302 | Get Quote |
|
| 10MG | 447 | Get Quote |
|
| 25MG | 714 | Get Quote |
|
| 50MG | 1017 | Get Quote |
|
| 100MG | 1368 | Get Quote |
|
| 500MG | 2673 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameApomine
-
NoteResearch use only, not for human use.
-
Brief DescriptionApomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase and stimulates low-density lipoprotein receptor activity.
-
DescriptionApomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase and stimulates low-density lipoprotein receptor activity. Apomine enhances the antitumor effect of lovastatin on myeloma cells by downregulating 3-hydroxy-3-methylglutaryl-CoA reductase.
-
In Vitro——
-
In Vivo——
-
SynonymsAPB-231-A-2 | SK&F-99085 | SR-45023A | SR-9223i | APB-231-A2
-
PathwayMetabolic Enzyme/Protease
-
TargetHMGCR
-
RecptorParasite
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number126411-13-0
-
Formula Weight562.665
-
Molecular FormulaC28H52O7P2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC(C)OP(=O)(OC(C)C)C(Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)P(=O)(OC(C)C)OC(C)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Paul R Gilson, et al. Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity. J Med Chem. 2017 Feb 9;60(3):1171-1188.
molnova catalog
related products
-
Rosuvastatin calcium
A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM.
-
Atorvastatin lactone
Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
-
Monacolin J
Monacolin J is a cholesterol biosynthesis inhibitor.
