Cart
sales@molnova.com
Mitonafide
CAS No. 54824-17-8
Mitonafide( NSC300288 | NSC-300288 | NSC 300288 | Mitonafide )
Catalog No. M27823 CAS No. 54824-17-8
Mitonafide suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
|
| 2MG | 38 | In Stock |
|
| 5MG | 61 | In Stock |
|
| 10MG | 92 | In Stock |
|
| 25MG | 188 | In Stock |
|
| 50MG | 305 | In Stock |
|
| 100MG | 499 | In Stock |
|
| 200MG | 713 | In Stock |
|
| 500MG | 1070 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMitonafide
-
NoteResearch use only, not for human use.
-
Brief DescriptionMitonafide suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.
-
DescriptionMitonafide suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.
-
In Vitro——
-
In VivoMitonafide (0.5 and 1 mg/kg, i.p., 1-7 days) shows antitumoral potency in S-180 bearing mice.Mitonafide (5 mg/kg, i.p., twice a day) shows anticancer activity in HepG2 xenograft model.Mitonafide (single i.p. injection, S-180 bearing mice) shows the LD50 value of 10.0 mg/kg. Animal Model:S-180 bearing mice Dosage:0.5 mg/kg and 1 mg/kg Administration:Intraperitoneal injection (i.p.) for 1-7 days Result:Increased in median survival times.Animal Model:HepG2 xenograft model Dosage:5 mg/kg Administration:Intraperitoneal injection (i.p.), twice a day.Result:Exhibited a relative tumor increment rates (T/C) value of 28.8%.
-
SynonymsNSC300288 | NSC-300288 | NSC 300288 | Mitonafide
-
PathwayGPCR/G Protein
-
TargetAntibacterial
-
RecptorATP citrate lyase|GPR40|GPR120
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number54824-17-8
-
Formula Weight313.313
-
Molecular FormulaC16H15N3O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 62.5 mg/mL (199.48 mM)
-
SMILESCN(C)CCN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Hara T, Hirasawa A, Sun Q, et al. Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 2009;380(3):247-255.
molnova catalog
related products
-
Meldrum's acid
Meldrum's acid is an antimicrobial agent used in deodorant. Meldrum's acid-based multicomponent reaction is a potential tool to prepare novel polymers.
-
Imipenem
Imipenem (MK-0787) is a broad-spectrum, semi-synthetic beta-lactam carbapenem that has broad antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria.
-
Indolicidin
Indolicidin is comprised of 13 amino acids, 5 of which are tryptophan residues, and the carboxylterminal arginine is carboxamidated. Indolicidin has the highest tryptophan content of any known protein.Indolicidin is comprised of 13 amino acids, 5 of which are tryptophan residues, and the carboxylterminal arginine is carboxamidated.
