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L-822179
CAS No. 215874-86-5
L-822179( L 822179 | L822179 | L-822,179 | L 822,179 | L822,179 )
Catalog No. M27776 CAS No. 215874-86-5
L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 109 | In Stock |
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| 25MG | 186 | In Stock |
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| 50MG | 272 | In Stock |
|
| 100MG | 389 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameL-822179
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NoteResearch use only, not for human use.
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Brief DescriptionL-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.
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DescriptionL-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.
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In VitroCell Viability Assay Cell Line:Primary mouse hippocampal culture Concentration:0.3 nM, 3 nM, 30 nM, 100 nM Incubation Time:24 h Result:Significantly reduced Aβ 1-42-induced cell death by 13% at a concentration of 100 nM. Significantly decreased the expression of GABAAR α5 subunit.
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In Vivo——
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SynonymsL 822179 | L822179 | L-822,179 | L 822,179 | L822,179
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PathwayOthers
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TargetOther Targets
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RecptorMIF
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Research Area——
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Indication——
Chemical Information
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CAS Number215874-86-5
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Formula Weight362.353
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Molecular FormulaC17H14N8O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCc1cc(no1)-c1nnc2c3ccccc3c(OCc3cn(C)nn3)nn12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Compound K
HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor.
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N1-Methylpseudouridi...
N1-Methylpseudouridine is a methylpseudouridine and enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density in mRNA.
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FGF basic (119-126) ...
bFGF (119-126) is a biological active peptide. (This peptide corresponds to human, bovine (119-126), mouse, rat (118-125) and Heparin-Binding Growth Factor 2 (118-125) residues of bFGF. It inhibits dimerization and activation of bFGF receptors.)
