U 89843A

CAS No. 157013-32-6

U 89843A( —— )

Catalog No. M27731 CAS No. 157013-32-6

U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 31 In Stock
5MG 52 In Stock
10MG 77 In Stock
25MG 181 In Stock
50MG 313 In Stock
100MG 421 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    U 89843A
  • Note
    Research use only, not for human use.
  • Brief Description
    U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.
  • Description
    U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.(In Vitro):In the alpha 1 beta 2 gamma 2 subtype of GABAA receptors expressed in human embryonic kidney cells, U 89843A dose-dependently enhanced 5 microM GABA-induced Cl- currents with a maximal enhancement of 362 +/- 91%, a half-maximal concentration of 2 +/- 0.4 microM and a slope factor of 1.1 +/- 0.4. U 89843A also inhibited [35S]t-butylbicyclophosphorothionate binding in rat cerebrocortical membranes with a similar half-maximal inhibitory concentration.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    acetylcholinesterase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    157013-32-6
  • Formula Weight
    321.85
  • Molecular Formula
    C16H24ClN5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.Cc1cc2c(nc(nc2n1C)N1CCCC1)N1CCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dafforn A, et al. Acetylcholinesterase inhibition by the ketone transition state analog phenoxyacetone and 1-halo-3-phenoxy-2-propanones. Biochem Biophys Res Commun. 1982 Jan 29;104(2):597-602.
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