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SMER3
CAS No. 67200-34-4
SMER3( SMER 3 | SMER3 )
Catalog No. M27713 CAS No. 67200-34-4
SMER 3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 47 | In Stock |
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| 10MG | 80 | In Stock |
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| 25MG | 160 | In Stock |
|
| 50MG | 245 | In Stock |
|
| 100MG | 357 | In Stock |
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| 500MG | 842 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSMER3
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NoteResearch use only, not for human use.
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Brief DescriptionSMER 3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response.
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DescriptionSMER 3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response.(In Vitro):SMER 3 and rapidly increased PFKFB3 protein levels. Accordingly, ubiquitin-bound PFKFB3 was lower in E2- or G1-treated HUVECs. Both agents increased deubiquitinase USP19 levels through GPER signaling.(In Vivo):SMER 3 diminishes binding of the F-box subunit Met30 to the SCF core complex in vivo and show evidence for SMER 3 directly binding to Met30.
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In VitroIn yeast cells, Met4 ubiquitination is blocked in cells exposed to SMER3 (0-60 μM). The met4Δ cells are less susceptible to growth inhibition by SMER3.Addition of SMER3 to the ligase reactions inhibited ubiquitination of Met4 by SCFMet30 in a dose-dependent manner. SMER3 significantly inhibits the binding of Met30 to Skp1, and does not affect the Skp1 and Met30 protein levels.
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In Vivo——
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SynonymsSMER 3 | SMER3
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PathwayOthers
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TargetOther Targets
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RecptormGluR5
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Research Area——
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Indication——
Chemical Information
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CAS Number67200-34-4
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Formula Weight224.18
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Molecular FormulaC11H4N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (55.76 mM)
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SMILESO=C1C2=CC=CC=C2C3=NC4=NON=C4N=C31
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003; 64(3):731-40.
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