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ML 154

CAS No. 1345964-89-7

ML 154( NCGC84 )

Catalog No. M27660 CAS No. 1345964-89-7

ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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5MG	107	In Stock
10MG	151	In Stock
25MG	278	In Stock
50MG	390	In Stock
100MG	539	In Stock
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Biological Information

Product Name

ML 154
Note

Research use only, not for human use.
Brief Description

ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
Description

ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
In Vitro

Western Blot Analysis Cell Line:CHO cells expressing NPSR Concentration:0.001 μM, 0.01 μM, 0.1 μM, 1 μM Incubation Time:30 min Result:Exhibited the most potent inhibition on NPS-induced ERK phosphorylation.
In Vivo

Animal Model:Male Wistar rats (300-350 g) injected with alcohol Dosage:1 mg/kg (10% Solutol, 10% N,N-dimethylacetamide, and 80% 10 mM PBS, pH 7.4) Administration:Intraperitoneal injection; once Result:Inhibited alcohol-induced central ERK phosphorylation in vivo.
Synonyms

NCGC84
Pathway

GPCR/G Protein
Target

Neuropeptide Y Receptor
Recptor

G2019S LRRK2
Research Area

——
Indication

——

Chemical Information

CAS Number

1345964-89-7
Formula Weight

545.48
Molecular Formula

C29H26BrN2PS
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (114.58 mM)
SMILES

[Br-].Cc1c([n+]2ccccc2n1C\C=C\c1ccccc1)P(=S)(c1ccccc1)c1ccccc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63(23):14821-14839.

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