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L-168049
CAS No. 191034-25-0
L-168049( L-168,049 )
Catalog No. M27645 CAS No. 191034-25-0
human glucagon receptor (hGR) antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 119 | In Stock |
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| 5MG | 107 | In Stock |
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| 10MG | 180 | In Stock |
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| 25MG | 377 | In Stock |
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| 50MG | 548 | In Stock |
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| 100MG | 784 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1609 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameL-168049
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NoteResearch use only, not for human use.
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Brief Descriptionhuman glucagon receptor (hGR) antagonist.
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Descriptionhuman glucagon receptor (hGR) antagonist(In Vitro):In Chinese hamster ovary cells expressing the human glucagon receptor, L-168049 increases the apparent EC50 of glucagon-stimulated adenylate cyclase and decreases maximal glucagon stimulation with a Kb of 25 nM. L-168049 blocks glucagon-stimulated cAMP formation in mouse liver membrane and inhibits glucagon (100 pM)-stimulated cAMP synthesis in CHO cells expressing the human glucagon receptor with IC50 of 41 nM .(In Vivo):In the liver of L-G6pc-/- mice, L-168049 (50 mg/kg body; p.o.) reduces Pck1 mRNA expression by half within 6 hours. L-168049 prevents the increase in G6pc expression in the kidney and gut .
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In VitroL-168049 (compound 49) inhibits glucagon (100 pM) stimulated cAMP synthesis in CHO cells expressing the human glucagon receptor (hGIAR) (IC50 of 41 nM). L-168049 blocks cAMP formation stimulated by glucagon in murine liver membranes. L-168049 increases the apparent EC50 for glucagon stimulation of adenylyl cyclase in Chinese hamster ovary cells expressing the human glucagon receptor and decreases the maximal glucagon stimulation observed, with a Kb of 25 nM.
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In VivoIn the liver of L-G6pc?/- mice, Pck1 mRNA expression is decreased by half 6 h after the administration of L-168049 (50 mg/kg body; p.o.), demonstrating the efficiency of the suppression of glucagon signaling. In agreement with the role of glucagon in the induction of extrahepatic gluconeogenesis, the administration of the L-168049 prevents the increase of the G6pc expression in both the kidneys and intestine of 6 h-fasted L-G6pc?/- mice.
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SynonymsL-168,049
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number191034-25-0
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Formula Weight467.79
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Molecular FormulaC24H20BrClN2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 50 mg/mL (106.89 mM)
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SMILESCCCOc1ccc(Br)cc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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PGP-4008
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Adrenocorticotropic ...
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Obestatin (rat)
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