ALR2-IN-1 is a potent and selective ALR2 inhibitor with an IC50 value of 1.42 μM. ALR2-IN-1 possesses both antiglycemic and antioxidant activities and can be used to study the complications of diabetes.

Glyceraldehyde is produced from the action of the enzyme glyceraldehyde dehydrogenase which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels glyceraldehyde can be a cytotoxin and a mutagen. A cytotoxin is a compound that kills cells.

BYAKANGELICINa main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitorand is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lead compound for the development of new type drugs for clinical use.