CID 5951923

Research use only, not for human use.

CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.

CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.(In Vitro):CID 5951923 (10 μM) inhibits the proliferation of cancer cell lines mainly in highly expressing KLF5 cells. CID 5951923 (0.001, 0.01, 0.1, 1, 10, 100 μM) inhibits proliferation of DLD-1 cells in a dose-dependent manner. CID 5951923 (10 μM) significantly decreases endogenous KLF5 levels in the DLD-1 cells, downregulates EGR1, and increases phosphorylation levels of pEGFFpY1068.

CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner.CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1.CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells. Cell Viability Assay Cell Line:DLD-1 and IEC-6 cells Concentration:0.001, 0.01, 0.1, 1, 10, 100 μM Incubation Time:48 h Result:Inhibited proliferation of DLD-1 cells with an IC50 of 1.6 μM.

——

——

Cell Cycle/DNA Damage

DNA/RNA Synthesis

ROCK2

——

——

749872-43-3

382.39

C16H18N2O7S

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (26.15 mM)

CN([C@H]1CCS(=O)(=O)C1)C(=O)COC(=O)\C=C\c1cccc(c1)[N+]([O-])=O

——

(-20℃)

With Ice Pack

≥ 2 years