Cart
sales@molnova.com
Adaphostin
CAS No. 241127-58-2
Adaphostin( NSC 680410 | 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate )
Catalog No. M27602 CAS No. 241127-58-2
Adaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 61 | In Stock |
|
| 10MG | 92 | In Stock |
|
| 25MG | 188 | In Stock |
|
| 50MG | 305 | In Stock |
|
| 100MG | 458 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 995 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAdaphostin
-
NoteResearch use only, not for human use.
-
Brief DescriptionAdaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.
-
DescriptionAdaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.(In Vitro):It also induces apoptosis in T-lymphoblastic human leukemia cell lines with IC50 ranging from 16.8 to 216.3 nM in vitro.(In Vivo):Adaphostin can damage both myeloid and lymphoid leukemia cells.
-
In VitroAdaphostin down-regulates p210bcr/abl in K562 cells and inhibits granulocyte colony formation in chronic myelogenous leukemia (CML) specimens at lower concentrations without enhanced toxicity in normal progenitors.Adaphostin-induced p53 up-regulation, DNA strand breaks, and ROS production in ML-1 cells is inhibited by N-acetylcysteine (NAC).
-
In Vivo——
-
SynonymsNSC 680410 | 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate
-
PathwayAngiogenesis
-
TargetBcr-Abl
-
RecptorCyclophilin J
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number241127-58-2
-
Formula Weight393.483
-
Molecular FormulaC24H27NO4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (127.07 mM)
-
SMILESOc1ccc(O)c(CNc2ccc(cc2)C(=O)OC23CC4CC(CC(C4)C2)C3)c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Zhao X, et al. Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity. Front Pharmacol. 2018 Feb 21;9:126.
molnova catalog
related products
-
Imatinib mesylate
An orally bioavailability mesylate salt of Imatinib, which is a multi-kinase inhibitor of v-Abl, c-Kit and PDGFR.
-
CHMFL-ABL-053
CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM.
-
WP1130
WP1130 (Degrasyn) is a small molecule that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression (IC50=1.8 uM).
