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Tropisetron
CAS No. 89565-68-4
Tropisetron( ICS 205-930 | Tropisetronum | Tropisteron )
Catalog No. M27585 CAS No. 89565-68-4
Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 40 | In Stock |
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| 10MG | 37 | In Stock |
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| 25MG | 68 | In Stock |
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| 50MG | 119 | In Stock |
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| 100MG | 184 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 477 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTropisetron
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NoteResearch use only, not for human use.
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Brief DescriptionTropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.
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DescriptionTropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.(In Vitro):The IC50 value of Tropisetron for the 5-HT3 receptor is 70.1 ± 0.9 nM. Tropisetron inhibits IL-2 production and antigen-induced proliferation in human peripheral T cells and inhibits signaling pathways that regulate the activation of transcription factors AP-1, NFAT, and NF-κB.(In Vivo):Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity.
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In Vitro——
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In Vivo——
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SynonymsICS 205-930 | Tropisetronum | Tropisteron
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorTRPM8
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Research Area——
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Indication——
Chemical Information
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CAS Number89565-68-4
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Formula Weight284.359
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Molecular FormulaC17H20N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bianchini G, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation. J Med Chem. 2021 Nov 25;64(22):16820-16837.
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