7-Hydroxycarbostyril( 3,4-Dihydro-7-hydroxycarbostyril )

Catalog No. M27524 CAS No. 70500-72-0

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Product Name

7-Hydroxycarbostyril
Note

Research use only, not for human use.
Brief Description

7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) is a kind of pharmaceutical intermediate.
Description

7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) is a kind of pharmaceutical intermediate.(In Vitro): VPC-80051 as the first small molecule inhibitor of hnRNP A1 splicing activity discovered to date by using a computer-aided drug discovery approach. The inhibitor was developed to target the RNA-binding domain (RBD) of hnRNP A1. Further experimental evaluation demonstrated that VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. This study lays the groundwork for future structure-based development of more potent and selective small molecule inhibitors of hnRNP A1 RNA interactions aimed at altering the production of cancer-specific alternative splice isoforms.
In Vitro

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In Vivo

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Synonyms

3,4-Dihydro-7-hydroxycarbostyril
Pathway

Others
Target

Other Targets
Recptor

TRPA1
Research Area

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Indication

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1.Takaya J, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23;137(50):15859-64.

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