RO8191( CDM-3008 | RO4948191 )

Catalog No. M27515 CAS No. 691868-88-9

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an agonist of interferon (IFN) receptor.

Purity : >98% (HPLC)

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2MG	50	In Stock
5MG	85	In Stock
10MG	140	In Stock
25MG	268	In Stock
50MG	393	In Stock
100MG	592	In Stock
200MG	Get Quote	In Stock
500MG	1228	In Stock
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Biological Information

Product Name

RO8191
Note

Research use only, not for human use.
Brief Description

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an agonist of interferon (IFN) receptor.
Description

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an agonist of interferon (IFN) receptor.(In Vitro):RO8191 strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells.(In Vivo):RO8191 significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice.
In Vitro

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In Vivo

——
Synonyms

CDM-3008 | RO4948191
Pathway

Microbiology/Virology
Target

HCV
Recptor

thyrotropin receptor (TSHR)
Research Area

——
Indication

——

Chemical Information

CAS Number

691868-88-9
Formula Weight

373.218
Molecular Formula

C14H5F6N5O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 5 mg/mL (13.40 mM)
SMILES

FC(F)(F)c1cc(c2ccc3nc(cn3c2n1)-c1nnco1)C(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Neumann S, et al. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54.

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