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ARN14974

CAS No. 1644158-57-5

ARN14974( —— )

Catalog No. M27444 CAS No. 1644158-57-5

ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 103 Get Quote
2MG 49 Get Quote
5MG 80 Get Quote
10MG 125 Get Quote
25MG 242 Get Quote
50MG 439 Get Quote
100MG 626 Get Quote
200MG 897 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
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Biological Information

  • Product Name
    ARN14974
  • Note
    Research use only, not for human use.
  • Brief Description
    ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM.
  • Description
    ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM.
  • In Vitro
    ARN14974 (20 μM; 24 hours;SW403 and Raw 264.7 cells) inhibits acid ceramidase (AC) in a complex cellular environment, leading to the intended biochemical response, that is, increased ceramide and decreased sphingosine levels.
  • In Vivo
    ARN14974 (10 mg/kg; i.p.; mice) causes a substantial reduction in AC activity in multiple organs, including brain, liver, heart, lungs, and kidney.ARN14974 (10 mg/kg; i.p.) quickly enters the bloodstream after a single intraperitoneal administration in mice, reaching a maximal plasma concentration, Cmax, of 1767.9 ng/mL and displaying a half-life time of 458 min in circulation. ARN14974 (1 mg/kg; i.v.) shows a Cmax and a half-life time of 628 ng/mL and 72 min, respectively.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1644158-57-5
  • Formula Weight
    404.441
  • Molecular Formula
    C24H21FN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (123.63 mM)
  • SMILES
    Fc1ccc(cc1)-c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Min-Kyung Lee, et al. Tellimoside, a flavonol glycoside from Brasenia schreberi, inhibits the growth of cyanobacterium (Microcystis aeruginosa LB 2385). Journal of the Korean Society for Applied Biological Chemistry volume 56, pages 117-121 (2013).
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