Isoflupredone Acetate( —— )

Catalog No. M27374 CAS No. 338-98-7

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Product Name

Isoflupredone Acetate
Note

Research use only, not for human use.
Brief Description

Isoflupredone Acetate is a corticosteroid with the activity of topical anti-inflammatory.
Description

Isoflupredone Acetate is a corticosteroid with the activity of topical anti-inflammatory.
In Vitro

Isoflupredone acetate (10-4, 10-7, or 10-10 M; 48 or 96 h) mitigates the inflammatory and catabolic effects of IL-1β in synovial and osteochondral explants (from equine cadavers) to a greater extent in low concentrations (10-7 M and 10-10 M) than the high concentration (10-4 M).
In Vivo

Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline (HY-B0275). Animal Model:96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion of Mannheimia haemolytica)Dosage:0.05 mg/kg Administration:i.m.; on days 2 and 4 after the challenge Result:Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers.Prevented these reductions and resulted in faster clinical improvement when co-treated with Oxytetracycline (HY-B0275).
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

serotonin
Research Area

——
Indication

——

CAS Number

338-98-7
Formula Weight

420.477
Molecular Formula

C23H29FO6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (297.29 mM)
SMILES

CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C
Chemical Name

——

1.Wang H, et al. Identification and determination of four metabolites of mangiferin in rat urine. J Pharm Biomed Anal. 2007;45(5):793-798.

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