Ormetoprim

Research use only, not for human use.

Ormetoprim, an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture.

Ormetoprim, an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture.(In Vivo):Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL).Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration.

——

Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL).Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration. Animal Model:Hybrid striped bass (565-805 g)Dosage:50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis)Administration:I.p. and p.o. administration Result:I.p.: t1/2(elim)=7.5 h; t1/2(abs)=5.4 h; Cmax=1.2 μg/mL.P.o.: t1/2(elim)=3.9 h; t1/2(abs)=3.9 h; Cmax=1.6 μg/mL; F=78.5%.

Ro 5-9754 | Ro-5-9754 | Ro5-9754

Microbiology/Virology

Antibiotic

papain-like protease (PLpro)

——

——

6981-18-6

274.324

C14H18N4O2

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (91.13 mM)

COc1cc(C)c(Cc2cnc(N)nc2N)cc1OC

——

(-20℃)

With Ice Pack

≥ 2 years