Esomeprazole

Research use only, not for human use.

Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis.

Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).(In Vivo):In an orthotopic transplantation nude mouse model, Esomeprazole reduced lung metastasis of MDA-MB-231 breast cancer cells.

Esomeprazole (25-100 μM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification. Cell Viability Assay Cell Line:MDA-MB-468 cells Concentration:25 μM, 50 μM, 75 μM, 100 μM Incubation Time:20 hours Result:Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis. Animal Model:C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury Dosage:30 mg/kg, 300 mg/kg Administration:Oral gavage; daily; for 19 or 11 days Result:Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

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Membrane Transporter/Ion Channel

Proton Pump

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119141-88-7

345.42

C17H19N3O3S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (361.88 mM)

O=[S@](C1=NC2=CC(OC)=CC=C2N1)CC3=NC=C(C)C(OC)=C3C

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(-20℃)

With Ice Pack

≥ 2 years