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Amtolmetin guacil
CAS No. 87344-06-7
Amtolmetin guacil( —— )
Catalog No. M27126 CAS No. 87344-06-7
Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 39 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 40 | In Stock |
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| 25MG | 65 | In Stock |
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| 50MG | 93 | In Stock |
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| 100MG | 138 | In Stock |
|
| 200MG | 184 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAmtolmetin guacil
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NoteResearch use only, not for human use.
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Brief DescriptionAmtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.
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DescriptionAmtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.
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In VitroAmtolmetin guacil (100 μM; 0-60 min) converts to TMT (Tolmetin, HY-B1799) along with MED5 (1-methyl-5-p-methylbenzoyl-pyrrol-2-acetamido aceticacid) in rat fresh plasma and rat liver microsomal, rapidly converts to MED5 and MED5 methyl ester without yielding TMT in human fresh plasma and human liver microsomes.
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In VivoAnimal Model:Male Wistar ratsDosage:50 mg/kg Administration:p.o.; single dosage Result:Pharmacokinetic Parameters of Amtolmetin guacil in male Wistar rats.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorUSP30
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Research Area——
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Indication——
Chemical Information
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CAS Number87344-06-7
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Formula Weight420.465
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Molecular FormulaC24H24N2O5
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Purity>98% (HPLC)
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Solubility——
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SMILESCOc1ccccc1OC(=O)CNC(=O)Cc1ccc(C(=O)c2ccc(C)cc2)n1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Arthur F Kluge, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659.
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