Palmitelaidic Acid

Research use only, not for human use.

Palmitelaidic Acid is one of the most abundant fatty acids in serum and tissue.

Palmitelaidic Acid is one of the most abundant fatty acids in serum and tissue.(In Vitro):Palmitelaidic Acid, described as lipokine, increases glucose uptake by modulation of 5'AMP-activated protein kinase (AMPK), as well as increasing lipolysis by activation of peroxisome proliferator-activated receptor-α (PPARα), in adipose tissue.(In Vivo):C57BL6 and PPARα knockout (KO) mice were fed for 12 weeks with a standard diet (SD) or high-fat diet (HF), and in the last 2 weeks were treated with oleic or Palmitelaidic Acid. Palmitelaidic Acid promoted a faster uptake of glucose in the body, associated with higher insulin concentration; however, even when stimulated with insulin, Palmitelaidic Acid did not modulate the insulin pathway (AKT, IRS). Palmitelaidic Acid increased the phosphorylation of AMPK, upregulated glucokinase and downregulated SREBP-1. Regarding AMPK downstream, Palmitelaidic Acid increased the production of FGF-21 and stimulated the expression of PPARα. Palmitelaidic Acid treatment did not increase AMPK phosphorylation, modulate glucokinase or increase FGF-21 in liver of PPARα KO mice.

The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Palmitoleic acid has been correlated with multiple cardiometabolic risk factors, including high blood pressure, total cholesterol, TGs, apoA-I, apoB, and endothelial dysfunction.

Palmitoleic acid promotes a faster uptake of glucose in the body, associated with higher insulin concentration. Palmitoleic acid increases the phosphorylation of AMPK, up-regulates glucokinase and down-regulates SREBP-1. Regarding AMPK downstream, palmitoleic acid increases the production of FGF-21 and stimulates the expression of PPARα. Palmitoleic acid reduces body weight increase, ameliorates the development of hyperglycemia and hypertriglyceridemia, and improves insulin sensitivity. Furthermore, palmitoleic acid down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNFα and resistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver.

9-trans-Hexadecenoic acid | trans-Palmitoleic acid

Cytoskeleton/Cell Adhesion Molecules

Glucokinase

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10030-73-6

254.414

C16H30O2

>98% (HPLC)

In Vitro:?Ethanol : 100 mg/mL (393.07 m)

CCCCCC\C=C\CCCCCCCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years