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Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
CAS No. 2204226-02-6
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride( —— )
Catalog No. M27020 CAS No. 2204226-02-6
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 36 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 42 | In Stock |
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| 25MG | 69 | In Stock |
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| 50MG | 100 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameThalidomide-O-amido-PEG-C2-NH2 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionThalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
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DescriptionThalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMitochondrial Metabolism
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Research Area——
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Indication——
Chemical Information
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CAS Number2204226-02-6
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Formula Weight454.86
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Molecular FormulaC19H23ClN4O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (274.81 mM)
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SMILESCl.NCCOCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang Y, et al. A new point mutation in the iron-sulfur subunit of succinate dehydrogenase confers resistance to boscalid in Sclerotinia sclerotiorum. Mol Plant Pathol. 2015 Sep;16(7):653-61.
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