Cart
sales@molnova.com
Thalidomide-O-amido-C6-NH2 TFA
CAS No. 1950635-14-9
Thalidomide-O-amido-C6-NH2 TFA( Cereblon Ligand-Linker Conjugates 11 TFA | E3 Ligase Ligand-Linker Conjugates 25 TFA | E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate | Thalidomide-O-amido-C6-NH2 TFA )
Catalog No. M26948 CAS No. 1950635-14-9
Thalidomide-O-amido-C6-NH2 TFA, a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
|
| 5MG | 38 | In Stock |
|
| 10MG | 54 | In Stock |
|
| 25MG | 88 | In Stock |
|
| 50MG | 127 | In Stock |
|
| 100MG | 230 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameThalidomide-O-amido-C6-NH2 TFA
-
NoteResearch use only, not for human use.
-
Brief DescriptionThalidomide-O-amido-C6-NH2 TFA, a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.
-
DescriptionThalidomide-O-amido-C6-NH2 TFA, a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
-
In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
-
In Vivo——
-
SynonymsCereblon Ligand-Linker Conjugates 11 TFA | E3 Ligase Ligand-Linker Conjugates 25 TFA | E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate | Thalidomide-O-amido-C6-NH2 TFA
-
PathwayOthers
-
TargetOther Targets
-
RecptorDNA replication| HCMV| Nucleoside Analogue
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1950635-14-9
-
Formula Weight544.484
-
Molecular FormulaC23H27F3N4O8
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (183.66 mM)
-
SMILESOC(=O)C(F)(F)F.NCCCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
OD1
Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a persistent Na+ current at hNav1.7 channel. Increases hyperpolarization at Nav1.4 and Nav1.6 channels. Induces spontaneous pain in vivo.
-
Foxy-5 TFA(881188-51...
Foxy-5 is a peptide that mimics the WNT5A protein and is expected to reduce the mobility of the cancer cells. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells.
-
4,5-Dichlorocatechol
4,5-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71.
