TUG-424

Research use only, not for human use.

TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).

TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).(In Vitro):In the presence of the same glucose concentration, the approximately 2-fold stimulation of secretion by TUG-424 in the presence of 12 mM glucose is comparable to that induced by palmitate. Increasing concentrations (100 nM to 10 μM) of TUG-424 enhances glucose-stimulated insulin secretion significantly already at 100 nM and with a maximal effect at 3 μM. Basal insulin secretion at 2.8 mM glucose is slightly but significantly reduces by TUG-424 .

Increasing concentrations (100 nM to 10 μM) of TUG-424 enhances glucose-stimulated insulin secretion significantly already at 100 nM and with a maximal effect at 3 μM. The approximately 2-fold stimulation of secretion by TUG-424 in the presence of 12 mM glucose is comparable to that induced by palmitate in the presence of the same glucose concentration. Basal insulin secretion at 2.8 mM glucose is slightly but significantly reduces by TUG-424.

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TUG424

Others

Other Targets

Human Endogenous Metabolite

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1082058-99-8

264.324

C18H16O2

>98% (HPLC)

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Cc1ccccc1C#Cc1ccc(CCC(O)=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years