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Belzutifan
CAS No. 1672668-24-4
Belzutifan( MK-6482 | PT2977 )
Catalog No. M26797 CAS No. 1672668-24-4
PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 is an orally active and selective HIF-2α inhibitor (IC50: 9 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 140 | In Stock |
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| 10MG | 260 | In Stock |
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| 25MG | 439 | In Stock |
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| 50MG | 644 | In Stock |
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| 100MG | 888 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBelzutifan
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NoteResearch use only, not for human use.
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Brief DescriptionPT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 is an orally active and selective HIF-2α inhibitor (IC50: 9 nM).
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DescriptionPT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile.(In Vitro):PT2977 effectively and dose-dependently decreased mRNA levels of human cyclin D1, a target gene regulated by HIF-2α. PT2977 reduced EPO expression in a rapid and dose-dependent manner.
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In Vitro——
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In Vivo——
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SynonymsMK-6482 | PT2977
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1672668-24-4
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Formula Weight383.34
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Molecular FormulaC17H12F3NO4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Acetone : 50 mg/mL (130.43 mM)
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SMILESCS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)[C@@H](F)[C@@H](O)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yue QX, et al. Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. Phytomedicine. 2010 Jul;17(8-9):606-13.
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