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NCT-502
CAS No. 1542213-00-2
NCT-502( N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide )
Catalog No. M26771 CAS No. 1542213-00-2
NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 54 | In Stock |
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| 2MG | 31 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 75 | In Stock |
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| 25MG | 154 | In Stock |
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| 50MG | 235 | In Stock |
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| 100MG | 406 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 913 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNCT-502
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NoteResearch use only, not for human use.
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Brief DescriptionNCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.
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DescriptionNCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.(In Vitro):NCT-502 is cytotoxic to MDA-MB-468 (EC50: 15.2 μM).
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In Vitro——
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In Vivo——
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SynonymsN-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorCrimean-Congo hemorrhagic fever virus (CCHFV)| Nucleoside Antimetabolite/Analog
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Research Area——
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Indication——
Chemical Information
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CAS Number1542213-00-2
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Formula Weight395.45
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Molecular FormulaC18H20F3N5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 130 mg/mL (328.74 mM)
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SMILESCc1cc(C)nc(NC(=S)N2CCN(CC2)c2ccc(cn2)C(F)(F)F)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.
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