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Methotrexate metabolite
CAS No. 19741-14-1
Methotrexate metabolite( DAMPA )
Catalog No. M26754 CAS No. 19741-14-1
Methotrexate metabolite is the active metabolite of Methotrexate which is a folic acid antagonist. Methotrexate metabolite inhibits parasite growth.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 25MG | 46 | In Stock |
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| 50MG | 72 | In Stock |
|
| 100MG | 108 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 272 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMethotrexate metabolite
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NoteResearch use only, not for human use.
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Brief DescriptionMethotrexate metabolite is the active metabolite of Methotrexate which is a folic acid antagonist. Methotrexate metabolite inhibits parasite growth.
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DescriptionMethotrexate metabolite is the active metabolite of Methotrexate which is a folic acid antagonist. Methotrexate metabolite inhibits parasite growth.(In Vitro):Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR).
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In Vitro——
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In Vivo——
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SynonymsDAMPA
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PathwayCell Cycle/DNA Damage
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TargetAntifolate
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RecptorAntibiotic| Bacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number19741-14-1
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Formula Weight325.332
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Molecular FormulaC15H15N7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (15.37 mM)
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SMILESCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cerón JM, et al. The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells. Peptides. 2010 Aug;31(8):1494-503.
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