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LRE1

CAS No. 1252362-53-0

LRE1( —— )

Catalog No. M26744 CAS No. 1252362-53-0

LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LRE1
  • Note
    Research use only, not for human use.
  • Brief Description
    LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.
  • Description
    LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.(In Vitro):LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition. LRE1 binds to the bicarbonate activator binding site and suppresses soluble adenylyl cyclase (sAC) via a unique allosteric mechanism.
  • In Vitro
    Western Blot Analysis Cell Line:Mouse cauda sperm Concentration:0.5-100 μM Incubation Time:60 minutes Result:LRE1 inhibits sAC dependent sperm capacitation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    S1PR1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1252362-53-0
  • Formula Weight
    280.77
  • Molecular Formula
    C12H13ClN4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (445.19 mM)
  • SMILES
    Nc1nc(Cl)cc(n1)N(Cc1cccs1)C1CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bigaud M, et al. Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism. PLoS One. 2016 Dec 22;11(12):e0168252.
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