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Home - Products - Membrane Transporter/Ion Channel - iGluR - JNJ-61432059

JNJ-61432059

CAS No. 2035814-50-5

JNJ-61432059( —— )

Catalog No. M26724 CAS No. 2035814-50-5

JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR(pIC50: 9.7).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 258 In Stock
5MG 235 In Stock
10MG 335 In Stock
25MG 561 In Stock
50MG 732 In Stock
100MG 977 In Stock
200MG 1321 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    JNJ-61432059
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR(pIC50: 9.7).
  • Description
    JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR(pIC50: 9.7).(In Vivo):In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    SHMT1| SHMT2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2035814-50-5
  • Formula Weight
    443.482
  • Molecular Formula
    C25H22FN5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (112.75 mM)
  • SMILES
    OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.
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