Fluorofenidone( AKF-PD )

Catalog No. M26688 CAS No. 848353-85-5

Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway.

Purity : >98% (HPLC)

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HNMR

HPLC

MSDS

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Biological Information

Product Name

Fluorofenidone
Note

Research use only, not for human use.
Brief Description

Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway.
Description

Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an analogue of AMR69. Which displays equivalent lower toxicity, antifibrotic activity, and longer half-life.
In Vitro

——
In Vivo

——
Synonyms

AKF-PD
Pathway

Others
Target

Other Targets
Recptor

——
Research Area

——
Indication

——

Chemical Information

CAS Number

848353-85-5
Formula Weight

203.216
Molecular Formula

C12H10FNO
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 140 mg/mL (688.94 mM)
SMILES

Cc1ccc(=O)n(c1)-c1cccc(F)c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.

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