5-Methoxytryptophol

Research use only, not for human use.

5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.

5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.(In Vitro):In MC3T3-E1 cells, most of the 5-methoxytryptophol doses reduced slightly the metabolic activity of osteoblasts. After 14 days of cell culture, Rankl mRNA levels were decreased. 5-methoxytryptophol also induced a high osteocalcin secretion and mineralization capacity. In RAW264.7 cells, 5-methoxytryptophol decreased the number of osteoclast formed and its activity. 5-methoxytryptophol promoted activation of the ERK1/2 pathway through the phosphorylation of ERK, while LUZ addition suppressed this effect. In conclusion, 5-methoxytryptophol inhibits osteoclastogenesis and promoting osteoblast differentiation.

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Methoxytryptophol | 2-(5-Methoxy-1H-indol-3-yl)ethanol

Proteasome/Ubiquitin

Endogenous Metabolite

NSD2-PWWP1

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712-09-4

191.23

C11H13NO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (522.93 mM)

COc1ccc2[nH]cc(CCO)c2c1

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(-20℃)

With Ice Pack

≥ 2 years