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5-Methoxytryptophol
CAS No. 712-09-4
5-Methoxytryptophol( Methoxytryptophol | 2-(5-Methoxy-1H-indol-3-yl)ethanol )
Catalog No. M26544 CAS No. 712-09-4
5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 50MG | 39 | In Stock |
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| 100MG | 63 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name5-Methoxytryptophol
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NoteResearch use only, not for human use.
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Brief Description5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.
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Description5-Methoxytryptophol is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.(In Vitro):In MC3T3-E1 cells, most of the 5-methoxytryptophol doses reduced slightly the metabolic activity of osteoblasts. After 14 days of cell culture, Rankl mRNA levels were decreased. 5-methoxytryptophol also induced a high osteocalcin secretion and mineralization capacity. In RAW264.7 cells, 5-methoxytryptophol decreased the number of osteoclast formed and its activity. 5-methoxytryptophol promoted activation of the ERK1/2 pathway through the phosphorylation of ERK, while LUZ addition suppressed this effect. In conclusion, 5-methoxytryptophol inhibits osteoclastogenesis and promoting osteoblast differentiation.
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In Vitro——
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In Vivo——
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SynonymsMethoxytryptophol | 2-(5-Methoxy-1H-indol-3-yl)ethanol
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorNSD2-PWWP1
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Research Area——
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Indication——
Chemical Information
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CAS Number712-09-4
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Formula Weight191.23
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Molecular FormulaC11H13NO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (522.93 mM)
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SMILESCOc1ccc2[nH]cc(CCO)c2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dilworth D, et al. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2022 Jan;18(1):56-63.
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