ZK824190( —— )

Catalog No. M26523 CAS No. 2254001-81-3

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Datasheet

HNMR

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Product Name

ZK824190
Note

Research use only, not for human use.
Brief Description

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA).
Description

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.(In Vivo):In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2 mg/kg; p.o.) exhibited a relatively high oral availability(F = 55%; Cmax= 0.64 g/mL and AUC = 2.2 h*g/mL) and a moderate half time of 2.8 h.
In Vitro

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In Vivo

ZK824190 (2?mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h). Animal Model:Rats with experimental autoimmune encephalomyelitis (EAE) model Dosage:2?mg/kg (Pharmacokinetic Analysis) Administration:PO Result:Oral availability F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL; T1/2=2.8 h.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

5-HT3
Research Area

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Indication

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1.Kilpatrick GJ, et al. 1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. Eur J Pharmacol. 1990 Jun 21;182(1):193-7.

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