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YS-49
CAS No. 132836-42-1
YS-49( —— )
Catalog No. M26515 CAS No. 132836-42-1
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 2MG | 53 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 275 | In Stock |
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| 50MG | 399 | In Stock |
|
| 100MG | 578 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1190 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameYS-49
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NoteResearch use only, not for human use.
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Brief DescriptionYS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
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DescriptionYS-49 is an activator of PI3K/Akt (a downstream target of RhoA).(In Vitro):In RAVSMC and RAW 264.7 cells, YS-49 (1-100 μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30 μM, respectively.At the transcriptional level, YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells .(In Vivo):In male Sprague Dawley rats,YS-49 (5 mg/kg; intraperitoneal injection; 8 hours) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.
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In VitroYS-49 (1-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively.YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level. Cell Viability Assay Cell Line:RAVSMC and RAW 264.7 cells Concentration:10 μΜ, 30 μΜ and 100?μΜ (RAVSMC cells); 1 μΜ, 10 μΜ and 100?μM (RAW 264.7 cells)Incubation Time:18 hours Result:Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC50 values of 22 and 30?μM, respectively. Western Blot Analysis Cell Line:RAVSMC and RAW 264.7 cells Concentration:10 μΜ, 30 μΜ and 100?μΜ Incubation Time:18 hours Result:Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.
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In VivoYS-49 (5?mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. Animal Model:Male Sprague Dawley rats (250-300?g)Dosage:5?mg/kg Administration:Intraperitoneal injection; 8 hours Result:Serum NOx levels were significantly reduced.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetRAAS
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RecptorAPE1| Parasite| Topoisomerase I| Topoisomerase II
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Research Area——
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Indication——
Chemical Information
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CAS Number132836-42-1
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Formula Weight386.289
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Molecular FormulaC20H20BrNO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (258.88 mM)
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SMILESBr.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pica Mattoccia L, et al. Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoni. Mol Biochem Parasitol. 1983 Jun;8(2):99-107.
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