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TM-25659
CAS No. 260553-97-7
TM-25659( —— )
Catalog No. M26484 CAS No. 260553-97-7
TM-25659 is a modulator of transcriptional co-activator with PDZ-binding motif (TAZ), with anti-osteoporotic and anti-obesity activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 10MG | 112 | In Stock |
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Biological Information
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Product NameTM-25659
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NoteResearch use only, not for human use.
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Brief DescriptionTM-25659 is a modulator of transcriptional co-activator with PDZ-binding motif (TAZ), with anti-osteoporotic and anti-obesity activities.
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DescriptionTM-25659 is a modulator of transcriptional co-activator with PDZ-binding motif (TAZ), with anti-osteoporotic and anti-obesity activities.(In Vitro):Treatment with TM-25659 (2, 10, 20, 100 μM) dose-dependently enhances nuclear TAZ localization and attenuates PPARγ-mediated adipocyte differentiation by facilitating PPARγ suppression activity of TAZ. Osteogenic gene expression is enhanced by TM-25659 (2, 10, 50 μM) and thereby osteoblast differentiation is increased.(In Vivo):In vivo, TM-25659 (50 mg/kg, i.p., every other day for 2 weeks) suppresses bone loss and decreases weight gain in an obesity model. The plasma concentration of TM-25659 declines with an approximate t1/2 of 7 or 10 h following i.v or p.o. administration respectively. The systemic clearance (CL) is 0.21 L/(h×kg) and the volume of distribution at steady-state (1.91 L/(h×kg)) is larger than the volume of total body fluids.
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In VitroCell Proliferation Assay Cell Line:3T3-L1 cells Concentration:2, 10, 20, 100 μM Incubation Time:6 days Result:Acted as a suppressor of PPARγ-dependent adipocyte differentiation.
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In VivoAnimal Model:C57BL6 mice (4- to 6-week-old )Dosage:50 mg/kg Administration:I.p., every other day for 2 weeks Result:Attenuated weight gain in these obese mice.Animal Model:Adult male Sprague-Dawley rats Dosage:10 mg/kg Administration:I.v. (2, 10 and 30 min), oral (15 and 30 min, and 1, 2, 4 and 8 h)Result:Oral administration for 4 weeks moderately but significantly attenuated weight gain and partly restored BMD in the OVX rats.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorHCV
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Research Area——
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Indication——
Chemical Information
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CAS Number260553-97-7
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Formula Weight500.6
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Molecular FormulaC30H28N8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 135 mg/mL (269.68 mM)
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SMILESCCCCc1nc2cc(-c3cccnc3)c(C)nc2n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Ac-Ile-Tyr(PO3H2)-Gl...
p60c-src substrate II, phosphorylated is a pentapeptide. p60c-src substrate II, phosphorylated is a p60c-src substrate II phosphorylated polypeptide. Protein phosphorylation is an important post-translationmodification of protein that is indispensible in biological regulations.
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NNMTi
NNMTi? is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM;?50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adipocytes 1-methylnicotinamide level (EC50 = 2.3 μM) without affecting related methyltransferases & enzymes in the NAD+ salvage pathwayNNMTi treatment will rescue age-related deficits in muSC activity to promote superior regeneration post-injury in aging muscle.
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Subtilisin
Subtilisin, also known as rubinase, is a serine protease of bacterial origin. This enzyme exhibits thermal stability, pH tolerance, and calcium-dependent stability, characteristics that make it suitable for use as an additive in detergents .
