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SP-8356
CAS No. 1454885-45-0
SP-8356( —— )
Catalog No. M26459 CAS No. 1454885-45-0
SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
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| 5MG | 150 | In Stock |
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| 10MG | 238 | In Stock |
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| 25MG | 449 | In Stock |
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| 50MG | 597 | In Stock |
|
| 100MG | 798 | In Stock |
|
| 200MG | 1079 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSP-8356
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NoteResearch use only, not for human use.
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Brief DescriptionSP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.
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DescriptionSP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.(In Vitro):In a time- and dose-dependent manner, SP-8356 (5-10 μM; 48 hours) inhibits the growth of various types of breast cancer cell lines. SP-8356 (10 μM; 48 hours) increases the percentage of MDA-MB231 cells in the S phase and decreases caspase-3 and cleaved PARP .(In Vivo):In a xenograft mouse model, SP-8356 (10 mg/kg; i.p.; every three days until the 42nd day) inhibits tumor growth . SP-8356 (50 mg/kg; p.o.; daily one day after carotid artery ligation for three weeks) prevents the formation of plaque and attenuates its vulnerability.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorCOX-2| ROS
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Research Area——
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Indication——
Chemical Information
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CAS Number1454885-45-0
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Formula Weight300.354
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Molecular FormulaC18H20O4
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Purity>98% (HPLC)
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Solubility——
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SMILES[H][C@@]12C[C@@]([H])(C(\C=C\c3cc(O)c(O)c(OC)c3)=CC1=O)C2(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10.
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