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SHIN1
CAS No. 2146095-85-2
SHIN1( RZ-2994 )
Catalog No. M26439 CAS No. 2146095-85-2
SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 151 | In Stock |
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| 5MG | 139 | In Stock |
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| 10MG | 207 | In Stock |
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| 25MG | 376 | In Stock |
|
| 50MG | 573 | In Stock |
|
| 100MG | 882 | In Stock |
|
| 200MG | 1209 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSHIN1
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NoteResearch use only, not for human use.
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Brief DescriptionSHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.
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DescriptionSHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.(In Vitro):SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells (IC50 = 10 nM). SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates. SHIN1 is particularly active against B-cell malignancies.
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In Vitro——
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In Vivo——
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SynonymsRZ-2994
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PathwayOthers
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TargetOther Targets
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RecptorHMG-CoA reductase
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Research Area——
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Indication——
Chemical Information
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CAS Number2146095-85-2
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Formula Weight400.482
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Molecular FormulaC24H24N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 66.67 mg/mL (166.48 mM)
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SMILESCC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7(3):138-44.
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