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SHIN1

CAS No. 2146095-85-2

SHIN1( RZ-2994 )

Catalog No. M26439 CAS No. 2146095-85-2

SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SHIN1
  • Note
    Research use only, not for human use.
  • Brief Description
    SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.
  • Description
    SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.(In Vitro):SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells (IC50 = 10 nM). SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates. SHIN1 is particularly active against B-cell malignancies.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RZ-2994
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HMG-CoA reductase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2146095-85-2
  • Formula Weight
    400.482
  • Molecular Formula
    C24H24N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 66.67 mg/mL (166.48 mM)
  • SMILES
    CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7(3):138-44.
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