RP 70676

Research use only, not for human use.

RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).

RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).(In Vitro):RP 70676 is a potent rabbit arterial ACAT inhibitor with IC50 of 40 nM and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues(IC50 : 44 nM). Murine macrophages the compound has an IC50 of 540 nM in whole cell P388D.(In Vivo):In NZW rabbits,RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels.

RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC50 of 540 nM.

RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits.

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Others

Other Targets

Human Endogenous Metabolite

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136609-26-2

416.59

C25H28N4S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (300.06 mM)

Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1

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(-20℃)

With Ice Pack

≥ 2 years