(Rac)-Acolbifene( EM-343 | (Rac)-EM-652 )

Catalog No. M26408 CAS No. 151533-34-5

(Rac)-Acolbifene is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

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MSDS

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1 mL x 10 mM in DMSO	69	In Stock
5MG	68	In Stock
10MG	107	In Stock
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Biological Information

Product Name

(Rac)-Acolbifene
Note

Research use only, not for human use.
Brief Description

(Rac)-Acolbifene is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities.
Description

(Rac)-Acolbifene is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities.(In Vitro):In T-47D cells, (Rac)-Acolbifene (0.110 nM) inhibits cell growth with an IC50 value of 0.110 nM.(In Vivo):In ovariectomized mice, (Rac)-Acolbifene (7.5 nM, 75 nM; oral) shows shows 63% and 84% antiuterotrophic inhibitions, respectively.
In Vitro

(Rac)-Acolbifene (EM-343; (Rac)-EM-652)? shows a inhibitory effect in T-47D cells with an IC50 value of 0.110 nM. Cell Viability Assay Cell Line:T-47D cells Concentration:0.110 nM Incubation Time:72 hours Result:Inhibited T-47D cells growth.
In Vivo

(Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice).
Synonyms

EM-343 | (Rac)-EM-652
Pathway

Others
Target

Other Targets
Recptor

FGFR1| FGFR2| FLT3| PDGFR| VEGFR1| VEGFR2| VEGFR3
Research Area

——
Indication

——

Chemical Information

CAS Number

151533-34-5
Formula Weight

457.57
Molecular Formula

C29H31NO4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (218.55 mM)
SMILES

CC1=C(C(Oc2cc(O)ccc12)c1ccc(OCCN2CCCCC2)cc1)c1ccc(O)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Tovar C, et al. Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. Cell Cycle. 2010 Aug 15;9(16):3364-75.

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