Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Dopamine Receptor - PNU-177864 hydrochloride

PNU-177864 hydrochloride

CAS No. 1783978-03-9

PNU-177864 hydrochloride( PNU-177864 (hydrochloride) )

Catalog No. M26387 CAS No. 1783978-03-9

PNU-177864 hydrochloride is a selective antagonist of D3 receptor with antischizophrenic activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 41 In Stock
5MG 29 In Stock
10MG 43 In Stock
25MG 72 In Stock
50MG 107 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PNU-177864 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    PNU-177864 hydrochloride is a selective antagonist of D3 receptor with antischizophrenic activity.
  • Description
    PNU-177864 hydrochloride is a selective antagonist of D3 receptor with antischizophrenic activity.(In Vivo):In Sprague-Dawley rats, PNU-177864 hydrochloride (8-200 mg/kg; gavage) induces phospholipidosis in unusual target organs including epididymis, hair follicles and pituitary.
  • In Vitro
    ——
  • In Vivo
    PNU-177864 (12.5-200 mg/kg; oral gavage; daily; for 2-4 weeks; Sprague-Dawley rats) treatment induces phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles. Animal Model:Male and female Sprague-Dawley rats (8-9-week-old)Dosage:12.5 mg/kg, 50 mg/kg (for 2 weeks), or 200 mg/kg; 8 mg/kg, 25 mg/kg, or 80 mg/kg (for 4 weeks)Administration:Oral gavage; daily; for 2-4 weeks Result:Induced phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles.
  • Synonyms
    PNU-177864 (hydrochloride)
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    VHL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1783978-03-9
  • Formula Weight
    438.89
  • Molecular Formula
    C18H22ClF3N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.O=S(=O)(NC1=CC=C(C=C1)CCNCCC)C2=CC=C(OC(F)(F)F)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 5-HT6/7 antagonist 1

    5-HT6/7 antagonist 1 is a dual 5-HT6/7/2A and D2 receptor antagonist used in the study of dementia and Alzheimer's disease.

  • ONC206

    ONC206 is an analogue of TRAIL inducer ONC201 and is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 also has broad-spectrum anti-tumor activity. ONC206 (Oncoceutics) is an imipiridone with nanomolar potency and analogue of ONC201, a selective dopamine receptor D2 (DRD2) antagonist currently being investigated in phase II clinical trials for serous endometrial cancer (SEC).??

  • Fluphenazine hydroch...

    Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor.

Sign In Join Free