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PNU-177864 hydrochloride
CAS No. 1783978-03-9
PNU-177864 hydrochloride( PNU-177864 (hydrochloride) )
Catalog No. M26387 CAS No. 1783978-03-9
PNU-177864 hydrochloride is a selective antagonist of D3 receptor with antischizophrenic activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 43 | In Stock |
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| 25MG | 72 | In Stock |
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| 50MG | 107 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePNU-177864 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPNU-177864 hydrochloride is a selective antagonist of D3 receptor with antischizophrenic activity.
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DescriptionPNU-177864 hydrochloride is a selective antagonist of D3 receptor with antischizophrenic activity.(In Vivo):In Sprague-Dawley rats, PNU-177864 hydrochloride (8-200 mg/kg; gavage) induces phospholipidosis in unusual target organs including epididymis, hair follicles and pituitary.
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In Vitro——
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In VivoPNU-177864 (12.5-200 mg/kg; oral gavage; daily; for 2-4 weeks; Sprague-Dawley rats) treatment induces phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles. Animal Model:Male and female Sprague-Dawley rats (8-9-week-old)Dosage:12.5 mg/kg, 50 mg/kg (for 2 weeks), or 200 mg/kg; 8 mg/kg, 25 mg/kg, or 80 mg/kg (for 4 weeks)Administration:Oral gavage; daily; for 2-4 weeks Result:Induced phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles.
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SynonymsPNU-177864 (hydrochloride)
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorVHL
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Research Area——
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Indication——
Chemical Information
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CAS Number1783978-03-9
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Formula Weight438.89
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Molecular FormulaC18H22ClF3N2O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.O=S(=O)(NC1=CC=C(C=C1)CCNCCC)C2=CC=C(OC(F)(F)F)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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