PNU-177864 hydrochloride

Research use only, not for human use.

PNU-177864 hydrochloride is a selective antagonist of D3 receptor with antischizophrenic activity.

PNU-177864 hydrochloride is a selective antagonist of D3 receptor with antischizophrenic activity.(In Vivo):In Sprague-Dawley rats, PNU-177864 hydrochloride (8-200 mg/kg; gavage) induces phospholipidosis in unusual target organs including epididymis, hair follicles and pituitary.

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PNU-177864 (12.5-200 mg/kg; oral gavage; daily; for 2-4 weeks; Sprague-Dawley rats) treatment induces phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles. Animal Model:Male and female Sprague-Dawley rats (8-9-week-old)Dosage:12.5 mg/kg, 50 mg/kg (for 2 weeks), or 200 mg/kg; 8 mg/kg, 25 mg/kg, or 80 mg/kg (for 4 weeks)Administration:Oral gavage; daily; for 2-4 weeks Result:Induced phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles.

PNU-177864 (hydrochloride)

GPCR/G Protein

Dopamine Receptor

VHL

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1783978-03-9

438.89

C18H22ClF3N2O3S

>98% (HPLC)

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Cl.O=S(=O)(NC1=CC=C(C=C1)CCNCCC)C2=CC=C(OC(F)(F)F)C=C2

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(-20℃)

With Ice Pack

≥ 2 years