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PI3K/mTOR Inhibitor-2
CAS No. 1848242-58-9
PI3K/mTOR Inhibitor-2( —— )
Catalog No. M26375 CAS No. 1848242-58-9
PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 147 | In Stock |
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| 5MG | 141 | In Stock |
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| 10MG | 226 | In Stock |
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| 25MG | 377 | In Stock |
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| 50MG | 528 | In Stock |
|
| 100MG | 714 | In Stock |
|
| 200MG | 918 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePI3K/mTOR Inhibitor-2
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NoteResearch use only, not for human use.
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Brief DescriptionPI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity.
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DescriptionPI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity.(In Vitro):PI3K/mTOR Inhibitor-2 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation with IC50s of 11.6 and 89.2 nM in cell assays, and good pharmacokinetic profile.(In Vivo):PI3K/mTOR Inhibitor-2 demonstrated in vivo efficacy in a PC-3M tumor xenograft model.
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In VitroPI3K/mTOR Inhibitor-2 (Compound 31) inhibits p-AKT and p-p70s6k in MCF-7 cells with IC50s of 11.6 and 89.2 nM, respectively.
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorHMG-CoA reductase
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Research Area——
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Indication——
Chemical Information
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CAS Number1848242-58-9
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Formula Weight478.85
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Molecular FormulaC20H13ClF2N4O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 8.33 mg/mL (17.40 mM)
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SMILESCOc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(Cl)c(=O)n2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Moriceau G, Roelofs AJ, Brion R, Redini F, Ebetion FH, Rogers MJ, Heymann D. Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth. Cancer. 2012 Feb 1;118(3):750-60.
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