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PF-06424439 methanesulfonate
CAS No. 1469284-79-4
PF-06424439 methanesulfonate( —— )
Catalog No. M26369 CAS No. 1469284-79-4
PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 63 | In Stock |
|
| 5MG | 52 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 305 | In Stock |
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| 100MG | 500 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-06424439 methanesulfonate
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM).
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DescriptionPF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM). PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate.(In Vivo):PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life.
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In Vitro——
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In VivoAnimal Model:Male low-density lipoprotein receptor (Ldlr) knockout mice (Ldlr-/-)Dosage:60 mg/kg Administration:P.o.; daily; for 3 days Result:Reduced plasma TG and cholesterol levels and decreased nonsignificant in circulating lipids.Animal Model:Male Wistar-Han ratsDosage:1 mg/kg Administration:I.v.Result:Showed moderate clearance and a short half-life with t1/2=1.39 h.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPI4Kα
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Research Area——
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Indication——
Chemical Information
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CAS Number1469284-79-4
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Formula Weight536.05
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Molecular FormulaC23H30ClN7O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (466.37 mM)
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SMILESCS(O)(=O)=O.Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Anna Lindsey Banka, et al. Quinazolinone derivatives as antiviral agents.WO2012087938A1
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