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PF-00356231 hydrochloride
CAS No. 820223-77-6
PF-00356231 hydrochloride( —— )
Catalog No. M26367 CAS No. 820223-77-6
PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 186 | In Stock |
|
| 10MG | 300 | In Stock |
|
| 25MG | 489 | In Stock |
|
| 50MG | 664 | In Stock |
|
| 100MG | 882 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePF-00356231 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.
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DescriptionPF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.(In Vitro):PF-00356231 hydrochloride shows potency against MMP-13, MMP-3, MMP-9, and MMP-8 with IC50s of 0.65 nM, 0.39 μM, 0.98 μM, and 1.7 μM, respectively. PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetMMP
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RecptorAutophagy| DPP-4
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Research Area——
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Indication——
Chemical Information
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CAS Number820223-77-6
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Formula Weight464.96
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Molecular FormulaC25H21ClN2O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20.83 mg/mL (44.80 mM)
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SMILESCl.OC(=O)C[C@@H](NC(=O)c1cc(cs1)-c1ccc(cc1)-c1ccncc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F, Mark M. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther. 2008 Apr;325(1):175-82.
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