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LY2365109 hydrochloride
CAS No. 1779796-27-8
LY2365109 hydrochloride( —— )
Catalog No. M26285 CAS No. 1779796-27-8
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | Get Quote |
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| 5MG | 72 | Get Quote |
|
| 10MG | 115 | Get Quote |
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| 25MG | 222 | Get Quote |
|
| 50MG | 335 | Get Quote |
|
| 100MG | 484 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameLY2365109 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
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DescriptionLY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.(In Vivo):LY2365109 hydrochloride increases seizure thresholds in mice.LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.
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In Vitro——
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In VivoLY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.LY2365109 hydrochloride increases seizure thresholds in mice. Animal Model:Male Sprague-Dawley rats (250-300 g)Dosage:0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg Administration:Oral administrationResult:Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetGlyT
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RecptorKetohexokinase (KHK)
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Research Area——
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Indication——
Chemical Information
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CAS Number1779796-27-8
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Formula Weight421.91
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Molecular FormulaC22H28ClNO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 31 mg/mL (73.48 mM)
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SMILESO=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.
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