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Hydroxybupropion
CAS No. 92264-81-8
Hydroxybupropion( 6-Hydroxybupropion | Hydroxybupropion, (+/-)- | Hydroxybupropione )
Catalog No. M26253 CAS No. 92264-81-8
Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 215 | In Stock |
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| 5MG | 188 | In Stock |
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| 10MG | 306 | In Stock |
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| 25MG | 511 | In Stock |
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| 50MG | 714 | In Stock |
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| 100MG | 977 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHydroxybupropion
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NoteResearch use only, not for human use.
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Brief DescriptionHydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent.
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DescriptionHydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake (IC50: 1.7 μM). Hydroxybupropion is also a nACh receptor antagonist more potent than Bupropion.(In Vitro):Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents.
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In Vitro——
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In Vivo——
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Synonyms6-Hydroxybupropion | Hydroxybupropion, (+/-)- | Hydroxybupropione
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PathwayOthers
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TargetOther Targets
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RecptorPEGs
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Research Area——
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Indication——
Chemical Information
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CAS Number92264-81-8
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Formula Weight255.74
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Molecular FormulaC13H18ClNO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (391.02 mM)
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SMILESCC(NC(C)(C)CO)C(=O)c1cccc(Cl)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570.
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