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GSK2983559 free acid
CAS No. 1579965-12-0
GSK2983559 free acid( —— )
Catalog No. M26238 CAS No. 1579965-12-0
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 75 | In Stock |
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| 10MG | 116 | In Stock |
|
| 25MG | 207 | In Stock |
|
| 50MG | 297 | In Stock |
|
| 100MG | 434 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGSK2983559 free acid
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NoteResearch use only, not for human use.
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Brief DescriptionGSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2).
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DescriptionGSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking many proinflammatory cytokine responses in human inflammatory bowel disease explant samples.
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In VitroGSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells. Cell Viability Assay Cell Line:THP-1 cells Concentration:1-1024 nM Incubation Time:2 hours Result:Inhibited IL-8 production with an IC50 of 1.34 nM.
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In VivoGSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse. Animal Model:C57BL/6 mice (female) injected with MDP (100 μg) Dosage:3 and 10 mg/kg Administration:Oral gavage; 3 and 10 mg/kg; once Result:Suppressed serum IL-6 levels in a dose-dependent manner.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorleucyl-tRNA synthetase| Ras-related GTP-binding protein D (RagD)
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Research Area——
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Indication——
Chemical Information
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CAS Number1579965-12-0
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Formula Weight538.53
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Molecular FormulaC21H23N4O7PS2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (9.28 mM)
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SMILESCC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCOP(O)(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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D-Glucose 6-phosphat...
In cells D-glucose 6-phosphate (G6P) is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the beginning of both glycolysis and the pentose phosphate pathways. It also can be stored as glycogen when blood glucose levels are high.
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8-Hydroxyguanosine
8-hydroxyguanosine (8-OHG) is a marker for measuring the rate of oxidative damage to nucleic acids and lipids.The concentration of 8-OHG in CSF in Parkinson's disease (PD) patients is approximately three-fold that in controls. The concentration of 8-OHG in CSF decreased significantly with the duration of disease. However, the concentration of 8-OHG in serum was not significantly altered in PD patients compared to that in controls.
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1,3-diethyl 2-(3-met...
1,3-diethyl 2-(3-methoxyphenyl)propanedioate is a compound used as a molecular building block.
