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GSK-3484862
CAS No. 2170136-65-7
GSK-3484862( —— )
Catalog No. M26234 CAS No. 2170136-65-7
Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity. Gsk-3484862 mediates the global demethylation of mouse embryonic stem cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 215 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 335 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 714 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1442 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK-3484862
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NoteResearch use only, not for human use.
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Brief DescriptionGsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity. Gsk-3484862 mediates the global demethylation of mouse embryonic stem cells.
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DescriptionGsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity. Gsk-3484862 mediates the global demethylation of mouse embryonic stem cells.
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In VitroGSK-3484862 (0-10 μM, 6 or 14 days) induces dramatic DNA methylation loss.GSK-3484862 (0-10 μM, 4 days) results in a modest reduction in DNMT1 protein level. Cell Viability Assay Cell Line:Murine embryonic stem cells (mESC, wild-type (WT) or Dnmt1/3a/3b triple knockout (TKO))Concentration:2 μM and 10 μM Incubation Time:6 or 14 days Result:Induced dramatic DNA methylation loss, with global CpG methylation levels falling from near 70% in WT mESC to less than 18% after 6 days.Western Blot Analysis Cell Line:Murine embryonic stem cells (mESC, wild-type (WT) or Dnmt1/3a/3b triple knockout (TKO))Concentration:2 μM and 10 μM Incubation Time:4 days Result:Resulted in a modest reduction in DNMT1 protein level.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2170136-65-7
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Formula Weight365.46
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Molecular FormulaC19H19N5OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20.83 mg/mL (57.00 mM)
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SMILESCCc1c(C#N)c(S[C@@H](C(N)=O)c2ccccc2)nc(N(C)C)c1C#N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pereira V, Le?a JM, Gaspar JM, Pereira AC, Marques JC. Rapid Determination of Sotolon in Fortified Wines Using a Miniaturized Liquid-Liquid Extraction Followed by LC-MS/MS Analysis. J Anal Methods Chem. 2018 Dec 16;2018:4393040.
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