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F-1
CAS No. 2244775-31-1
F-1( —— )
Catalog No. M26211 CAS No. 2244775-31-1
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 168 | In Stock |
|
| 5MG | 136 | In Stock |
|
| 10MG | 188 | In Stock |
|
| 25MG | 316 | In Stock |
|
| 50MG | 437 | In Stock |
|
| 100MG | 607 | In Stock |
|
| 200MG | 826 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameF-1
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NoteResearch use only, not for human use.
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Brief DescriptionF-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.
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DescriptionF-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetROS
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2244775-31-1
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Formula Weight519.02
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Molecular FormulaC22H27ClN8O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (240.84 mM)
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SMILESCOc1nc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(C)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hamilton JA, Bhamidipati SP, Kodali DR, Small DM. The interfacial conformation and transbilayer movement of diacylglycerols in phospholipid bilayers. J Biol Chem. 1991 Jan 15;266(2):1177-86.
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