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(E)-GABAB receptor antagonist 1
CAS No. 1611483-29-4
(E)-GABAB receptor antagonist 1( —— )
Catalog No. M26186 CAS No. 1611483-29-4
(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 147 | In Stock |
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| 5MG | 153 | In Stock |
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| 10MG | 225 | In Stock |
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| 25MG | 337 | In Stock |
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| 50MG | 462 | In Stock |
|
| 100MG | 631 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name(E)-GABAB receptor antagonist 1
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NoteResearch use only, not for human use.
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Brief Description(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.
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Description(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors.(In Vitro):(E)-GABAB receptor antagonist 1 reduces the maximum effect of IP3 in HEK293 cells overexpressing GABAB receptor and Gqi9 protein induced by agonist GABA, but does not alter EC50.
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In Vitro(E)-GABAB receptor antagonist 1 (compound 14) decreases agonist GABA-induced maximal effect of IP3 production in HEK293 cells overexpressing GABAB receptors and Gqi9 proteins without changing the EC50.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAdenine phosphoribosyltransferase
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Research Area——
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Indication——
Chemical Information
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CAS Number1611483-29-4
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Formula Weight304.38
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Molecular FormulaC18H24O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C(/C=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=O.[(E)]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Edamura K, et al. No self-injurious behavior was found in HPRT-deficient mice treated with 9-ethyladenine. Pharmacol Biochem Behav. 1998 Oct;61(2):175-9.
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