Duocarmycin TM
CAS No. 157922-77-5
Duocarmycin TM( —— )
Catalog No. M26182 CAS No. 157922-77-5
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 356 | Get Quote |
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| 10MG | 530 | Get Quote |
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| 25MG | 851 | Get Quote |
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| 50MG | 1152 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameDuocarmycin TM
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NoteResearch use only, not for human use.
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Brief DescriptionDuocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
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DescriptionDuocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
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In VitroDuocarmycin TM (60 μM; 4 d; BJAB and WSU-DLCL2 cells) is a cytotoxic agent that inhibits the proliferation of tumor cells.Cell Viability Assay Cell Line:BJAB and WSU-DLCL2 cells Concentration:60 μM Incubation Time:4 days Result:Inhibited the proliferation of tumor cells with IC50 values of 0.153 μM and 0.079μM for BJAB and WSU-DLCL2 cells, respectively.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA Alkylator
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number157922-77-5
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Formula Weight466.92
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Molecular FormulaC25H23ClN2O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 50 mg/mL (107.09 mM)
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SMILESCOc1cc2cc([nH]c2c(OC)c1OC)C(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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OBI-3424
OBI-3424 (AST-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent.
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Melflufen
Melflufen ?is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo; shows cytotoxic activity against lymphoma cell lines with IC50 of 0.011-0.92 uM, also shows significantly lower IC50 than melphalan in multiple myeloma cells.
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